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. 2016 Nov-Dec;32(6):1419-1424.
doi: 10.12669/pjms.326.10917.

Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy

Asmat Shaheen  1 , Rubina Nazli  2 , Sadia Fatima  3 , Roshan Ali  4 , Ihsanullah Khan  5 , Salim Khattak  6
Affiliations

Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy

Asmat Shaheen et al. Pak J Med Sci. 2016 Nov-Dec.

Abstract

Background and objectives: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women.

Methods: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student's t test was performed to evaluate the mean differences in patients and control.

Results: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value<0.001).: Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value<0.001).

Conclusion: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.

Keywords: Eclampsia; Hypertension; Normotensive pregnant women; Pre-eclampsia; Pregnancy; Visfatin.

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Conflict of interest statement

Declaration of interest: The authors declare that they have no competing interests.

Figures

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Fig.1
Enrollment and Flow of participants during study.
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