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Review
. 2016 Dec 1;8(12):e907.
doi: 10.7759/cureus.907.

IgG4-Related Hypophysitis: Case Report and Literature Review

Lauren Decker  1 , Angela M Crawford  2 , Gamaliel Lorenzo  3 , Martina Stippler  4 , Konstantin N Konstantinov  5 , Karen SantaCruz  1
Affiliations
Review

IgG4-Related Hypophysitis: Case Report and Literature Review

Lauren Decker et al. Cureus. .

Abstract

IgG4-related hypophysitis is a rare, inflammatory process of the pituitary that mimics more commonly seen pituitary tumors. We report a case of IgG4-related hypophysitis in a 16-year-old female with diabetes insipidus who was found to have IgG4-related hypophysitis based on tissue diagnosis. This entity has not been previously described in a pediatric patient. Recognition of certain inflammatory processes of the pituitary may lead to alternative means of diagnosis and medical management without a biopsy.

Keywords: igg4 related disease; lymphocytic hypophysitis; plasmacytic hypophysitis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Neuroimaging of Pituitary Mass
T1 MRI with contrast showing a 2 cm ring-enhancing suprasellar mass with effacement of the optic chiasm.
Figure 2
Figure 2. Pituitary Histopathology
Panel A: Hematoxylin- and eosin-stained section at 60x oil showing abundant plasma cells intermixed with occasional lymphocytes. Panel B: IgG4 immunostaining (red chromogen) at 10x revealing that a large percentage of the plasma cells are IgG4 positive. Panel C: IgG4 immunostaining at 10x confirming that nearly all of the inflammatory cells are plasma cells.
See this image and copyright information in PMC

References

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