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. 2016 Dec 27:4:146.
doi: 10.3389/fcell.2016.00146. eCollection 2016.

CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors

D Craig Ayre  1 , Sherri L Christian  1
Affiliations

CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors

D Craig Ayre et al. Front Cell Dev Biol. .
No abstract available

Keywords: CD24; GPI-anchored protein; cellular activation; extracellular stress signaling; protein interaction; receptor partner; signal transduction; surface receptor.

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Figures

Figure 1
Figure 1
CD24 operates through a combination of in cis and in trans partners to affect cell behavior in a cell-specific manner. (A) Schematic diagram showing the possible associations of CD24 with partner receptors and ligands. These associations selectively tune cellular responses. CD24 association with a signaling partner may be enhanced or inhibited through associative and dissociative ligands, respectively. The various CD24 interactions may not be mutually exclusive on a single cell, thus leading to a mosaic of cellular interactions and activation (green arrow) or inhibitory (red line) effects. (B) Interactions between specific CD24 glycosylations, ligands and known biological outcomes. Glycosylations are depicted as chains of carbohydrate monomers (blue squares) but do not represent a specific structure. The ligand-interacting, terminal carbohydrate moiety is indicated. L1CAM, Contactin and TAG-1 show both activating and inhibitory signals for neurogenesis as both effects can be mediated in discrete regions during CNS development.
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References

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