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Case Reports
. 2017 Aug;45(4):563-566.
doi: 10.1007/s15010-016-0978-8. Epub 2017 Jan 12.

Two cases of serious rhabdomyolysis during linezolid treatment

Arno M Lechner  1 , Eva Past  2 , Ulla Porsche  3 , Jan M Kern  4 , Uta Hoppe  5 , Ingrid Pretsch  5
Affiliations
Case Reports

Two cases of serious rhabdomyolysis during linezolid treatment

Arno M Lechner et al. Infection. 2017 Aug.

Abstract

Linezolid is an oxazolidinone antibiotic with activity against gram-positive organisms, particularly methicillin-resistant Staphylococcus aureus (MRSA). To the best of our knowledge, there are only two case reports on rhabdomyolysis in patients treated with linezolid. Here, we describe two cases of serious rhabdomyolysis: one in a patient with septic community-acquired (CA)-MRSA pneumonia and a second case in a patient with suspected catheter-related blood stream infection.

Keywords: Linezolid; MRSA pneumonia; MRSA sepsis; Rhabdomyolysis.

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Conflict of interest statement

All authors state, that for this work, there was no funding and there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Case 1: rise in creatine kinase concentrations in parallel to linezolid treatment. Asterisk linezolid trough concentrations on day 4 and day 8 (reference range 3.0–9.0 µg/mL). BD denotes twice daily, LZD linezolid, TD three times daily
Fig. 2
Fig. 2
Case 2: rise in creatine kinase and myoglobin levels in parallel to linezolid treatment. Asterisk linezolid trough concentrations on day 49 and day 54 (reference range 3.0–9.0 µg/mL). BD denotes twice daily, CK creatine kinase, LZD linezolid
See this image and copyright information in PMC

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