Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Jan 15;595(2):419-420.
doi: 10.1113/JP273260.

Progress in the biology and analysis of short chain fatty acids

Roel J Vonk  1 , Gerlof Reckman  1
Affiliations
Comment

Progress in the biology and analysis of short chain fatty acids

Roel J Vonk et al. J Physiol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Colonic metabolism and routes for systemic availability of short chain fatty acids (SCFAs)
Resistant starch, dietary fibre and other non‐absorbed carbohydrates are fermented by the microbiota (1) into sugar‐x and glucose. Lactate and SCFAs (2), and gasses such as hydrogen, methane and carbon dioxide (3), are subsequently formed. The latter can leave the colon by faecal excretion or are transported via the blood to the lungs and exhaled. Interconversion of lactate and SCFAs takes place via bacterial modifications (4). SCFAs can be taken up by colonic epithelial cells (5), excreted directly into the faeces (7), or excreted indirectly subsequent to their incorporation into bacteria (6). SCFAs taken up by epithelial cells can be used as an energy source inside the cell (butyrate) (8) or released into the bloodstream (9). After liver clearance (10) the remaining SCFAs reach the systemic circulation (11).
See this image and copyright information in PMC

Comment on

References

    1. Al‐Lahham SH, Peppelenbosch MP, Roelofsen H, Vonk RJ & Venema K (2010). Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta 1801, 1175–1183. - PubMed
    1. Boets E, Gomand SV, Deroover L, Preston T, Vermeulen K, De Preter V, Hamer HM, Van den Mooter G, De Vuyst L, Courtin CM, Annaert P, Delcour JA & Verbeke KA (2017). Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: a stable isotope study. J Physiol 595, 541–555. - PMC - PubMed
    1. Roelofsen H, Priebe MG & Vonk RJ (2010). The interaction of short‐chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. Benef Microbes 1, 433–437. - PubMed

LinkOut - more resources