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Meta-Analysis
. 2017 Mar;6(2):165-180.
doi: 10.2217/cer-2016-0045. Epub 2017 Jan 13.

CYD-TDV dengue vaccine: systematic review and meta-analysis of efficacy, immunogenicity and safety

Isabella Piassi Godói  1   2 , Livia Lovato Pires Lemos  2 , Vânia Eloisa de Araújo  3 , Braúlio Cesar Bonoto  1 , Brian Godman  4   5 , Augusto Afonso Guerra Júnior  1   2
Affiliations
Free article
Meta-Analysis

CYD-TDV dengue vaccine: systematic review and meta-analysis of efficacy, immunogenicity and safety

Isabella Piassi Godói et al. J Comp Eff Res. 2017 Mar.
Free article

Abstract

Introduction: Dengue virus (DENV) is a serious global health problem. CYD-TDC (Dengvaxia®) was the first vaccine to gain regulatory approval to try and address this problem.

Aim: Summarize all available evidence on the immunogenicity, efficacy and safety of the CYD-TDV dengue vaccine.

Method: Meta-analysis and systematic review.

Results: The best and worst immunogenicity results were for DENV4 and DENV1, respectively. Vaccine efficacy of 60% was derived from studies with participants aged 2-16 years old, with DENV4 and DENV2 presenting the best and worst results, respectively. Erythema and swelling were more frequent with CYD-TDV. No differences were detected for systemic adverse events.

Conclusion: CYD-TDV showed moderate efficacy in children and adolescents. From the immunogenicity results in adults, we can expect satisfactory efficacy from vaccination in this population.

Keywords: CYD-TDV; dengue; meta-analysis; systematic review; vaccines.

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