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Review
. 2017 Feb;31(2):218-224.
doi: 10.1038/eye.2016.299. Epub 2017 Jan 13.

Protecting retinal ganglion cells

T Z Khatib  1   2 , K R Martin  1   2   3   4
Affiliations
Review

Protecting retinal ganglion cells

T Z Khatib et al. Eye (Lond). 2017 Feb.

Abstract

Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including pharmacological neuroprotection, mesenchymal stem cells, and gene therapy approaches. We highlight potential pitfalls that need to be considered when developing these strategies and outline future directions, including the prospects for clinical trials.

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Conflict of interest statement

KRM is a consultant to Quethera Ltd. TZK declares no conflict of interest.

Figures

Figure 1
Figure 1
Summary of retinal ganglion cell (RGC) neuroprotection strategies.
See this image and copyright information in PMC

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