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Randomized Controlled Trial
. 2017 Oct;56(4):700-709.
doi: 10.1002/mus.25552. Epub 2017 Mar 24.

Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training

Martin Amadeus Rahbek  1 , Erik Elgaard Mikkelsen  1 , Kristian Overgaard  1 , Lotte Vinge  2 , Henning Andersen  2 , Ulrik Dalgas  1
Affiliations
Randomized Controlled Trial

Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training

Martin Amadeus Rahbek et al. Muscle Nerve. 2017 Oct.

Abstract

Introduction: It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG).

Methods: Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II-IV) were randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score.

Results: Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean adherence of 95 % ± 8. One dropout (PRT) could potentially be related to PRT. Both groups reported adverse events, including bulbar symptoms (n = 2) and increased fatigue (n = 3), but no change in QMG score was observed in either group. The PRT group showed increases in maximal strength and functional capacity.

Conclusions: Eight weeks of moderate to high intensity AT and PRT were feasible for most patients with mild MG. Maximal strength and functional capacity increased in the PRT group. Muscle Nerve 56: 700-709, 2017.

Keywords: aerobic training; exercise training; feasibility; myasthenia gravis; neurological disorder; progressive resistance training.

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