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. 2017 Jan 13;17(1):5.
doi: 10.1186/s12905-016-0356-9.

Clinical characteristics of genital chlamydia infection in pelvic inflammatory disease

Sung Taek Park  1 , Suk Woo Lee  1 , Min Jeong Kim  1 , Young Mo Kang  1 , Hye Min Moon  2 , Chae Chun Rhim  3
Affiliations

Clinical characteristics of genital chlamydia infection in pelvic inflammatory disease

Sung Taek Park et al. BMC Womens Health. .

Abstract

Background: Chlamydia infection in acute pelvic inflammatory disease (PID) is associated with serious complications including ectopic pregnancy, tubal infertility, Fitz-Hugh-Curtis syndrome and tubo-ovarian abscess (TOA). This study compared clinical and laboratory data between PID with and without chlamydia infection.

Methods: The medical records of 497 women who were admitted with PID between 2002 and 2011 were reviewed. The patients were divided into two groups (PID with and without chlamydia infection), which were compared in terms of the patients' characteristics, clinical presentation, and laboratory findings, including inflammatory markers.

Results: The chlamydia and non-chlamydia groups comprised 175 and 322 women, respectively. The patients in the chlamydia group were younger and had a higher rate of TOA, a longer mean hospital stay, and had undergone more surgeries than the patients in the non- chlamydia group. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and CA-125 level were higher in the chlamydia group than in the non-chlamydia group, but there was no significant difference in the white blood cell count between the two groups. The CA-125 level was the strongest predictor of chlamydia infection, followed by the ESR and CRP level. The area under the receiving operating curve for CA-125, ESR, and CRP was 0.804, 0.755, and 0.663, respectively.

Conclusions: Chlamydia infection in acute PID is associated with increased level of inflammatory markers, such as CA-125, ESR and CRP, incidence of TOA, operation risk, and longer hospitalization.

Keywords: CA-125; Chlamydia infection; Pelvic Inflammatory Disease.

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Figures

Fig. 1
Fig. 1
Mean CA-125 level in chlamydia and non-chlamydia group. After adjustment for age, smoking, and the incidence of TOA, a difference of CA-125 level between two groups showed a statistical significance (P = 0.001). P value was calculated by analysis of covariance
Fig. 2
Fig. 2
ROC curve of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and CA 125 in the diagnosis of chlamydia infection of PID
See this image and copyright information in PMC

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