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. 2017 Feb:55:109-112.
doi: 10.1016/j.ijid.2017.01.002. Epub 2017 Jan 11.

Dengue infection in pregnancy and its impact on the placenta

Christiane Fernandes Ribeiro  1 , Vânia Glória Silami Lopes  2 , Patrícia Brasil  3 , Andrea Rodrigues Cordovil Pires  4 , Roger Rohloff  5 , Rita Maria Ribeiro Nogueira  6
Affiliations
Free article

Dengue infection in pregnancy and its impact on the placenta

Christiane Fernandes Ribeiro et al. Int J Infect Dis. 2017 Feb.
Free article

Abstract

A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.

Keywords: dengue; placenta; pregnancy; vertical transmission.

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