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Review
. 2017 Jan;54(1):12-18.
doi: 10.1053/j.seminhematol.2016.11.001. Epub 2016 Nov 18.

Accumulation of DNA damage in the aged hematopoietic stem cell compartment

Isabel Beerman  1
Affiliations
Review

Accumulation of DNA damage in the aged hematopoietic stem cell compartment

Isabel Beerman. Semin Hematol. 2017 Jan.

Abstract

Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue-specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue-specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny, as well as propagated within the stem cell compartment through self-renewal divisions. This review will discuss the evidence for DNA damage accumulation in the aged HSC compartment, potential drivers, and finally the consequences of the acquired damage.

Keywords: Aging; DNA damage; HSC; Hematopoietic stem cells.

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Figures

Figure 1
Figure 1
Accumulation of various forms of DNA damage in the aged HSC compartment is present throughout aging of the HSC compartment, with certain combinations driving clonal expansion. The selection advantage conferred by mutations in these clones may also contribute to the progression towards hematopoietic malignancies.
See this image and copyright information in PMC

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