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Review
. 2017 Jan;54(1):25-32.
doi: 10.1053/j.seminhematol.2016.10.001. Epub 2016 Oct 19.

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging

Sarah E Latchney  1 , Laura M Calvi  2
Affiliations
Review

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging

Sarah E Latchney et al. Semin Hematol. 2017 Jan.

Abstract

The hematopoietic system has the remarkable ability to provide a lifelong supply of mature cells that make up the entire blood and immune system. However, similar to other adult stem cell niches, the hematopoietic system is vulnerable to the detrimental effects of aging. This is a substantial health concern as the trend for population aging continues to increase. Identifying mechanisms that underlie hematopoietic aging is vital for understanding hematopoietic-related diseases. In this review, we first discuss the cellular hierarchy of the hematopoietic system and the components that make up the surrounding hematopoietic niche. We then provide an overview of the major phenotypes associated with hematopoietic aging and discuss recent research investigating cell-intrinsic and cell-extrinsic mechanisms of hematopoietic stem cell (HSCs) aging. We end by discussing the exciting new concept of possibly reversing the HSC aging process along with outstanding questions that remain to be answered.

Keywords: Aging; Cell-extrinsic; Cell-intrinsic; Hematopoietic stem cells; Microenvironment.

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