Comment
doi: 10.1016/j.molmed.2016.12.009.
Epub 2017 Jan 12.
Germinal Center Lymphocyte Ratios and Successful HIV Vaccines
Affiliations
- PMID: 28089302
- DOI: 10.1016/j.molmed.2016.12.009
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Comment
Germinal Center Lymphocyte Ratios and Successful HIV Vaccines
Trends Mol Med.
2017 Feb.
Abstract
Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.
Copyright © 2016. Published by Elsevier Ltd.
Comment on
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Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085. Cell Rep. 2016. PMID: 27880897 Free PMC article.