Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome

Rada V Moerman^{1

2}, Suzanne Arends^{1

2}, Petra M Meiners^{1

2}, Arjan Vissink^{1

2}, Frederik K L Spijkervet^{1

2}, Frans G M Kroese^{1

2}, Elisabeth Brouwer^{1

2}, Hendrika Bootsma^{3

4}

Affiliations

¹ From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
² R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
³ From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands. h.bootsma@umcg.nl.
⁴ R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen. h.bootsma@umcg.nl.

PMID: 28089983
DOI: 10.3899/jrheum.160459

Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome

Rada V Moerman et al. J Rheumatol. 2017 Mar.

. 2017 Mar;44(3):292-296.

doi: 10.3899/jrheum.160459. Epub 2017 Jan 15.

Authors

Rada V Moerman^{1

2}, Suzanne Arends^{1

2}, Petra M Meiners^{1

2}, Arjan Vissink^{1

2}, Frederik K L Spijkervet^{1

2}, Frans G M Kroese^{1

2}, Elisabeth Brouwer^{1

2}, Hendrika Bootsma^{3

4}

Affiliations

¹ From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
² R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen.
³ From the Departments of Rheumatology and Clinical Immunology and Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands. h.bootsma@umcg.nl.
⁴ R.V. Moerman, MD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; S. Arends, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; P.M. Meiners, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; A. Vissink, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.K. Spijkervet, MD, PhD, Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen; F.G. Kroese, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; E. Brouwer, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen. h.bootsma@umcg.nl.

PMID: 28089983
DOI: 10.3899/jrheum.160459

Abstract

Objective: We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS).

Methods: Patients with pSS treated with RTX (n = 18) or ABA (n = 13) and having a DAS28 erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) level ≥ 3.2 at baseline were selected. Generalized estimating equations were used to analyze the DAS28 and ESSDAI articular domain over time.

Results: In the RTX group, DAS28-ESR/CRP decreased significantly up to 48 weeks. In the ABA group, DAS28-ESR/CRP decreased significantly up to 24 weeks. DAS28 correlated significantly with ESSDAI articular domain.

Conclusion: DAS28 is useful to evaluate the effect of biologicals on articular involvement in patients with pSS.

Keywords: 28-JOINT DISEASE ACTIVITY SCORE; ARTICULAR INVOLVEMENT; BIOLOGICALS; ESSDAI ARTICULAR DOMAIN; PRIMARY SJÖGREN SYNDROME.

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Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome

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Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome

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