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Case Reports
. 2017 Jul 10;16(3):265-269.
doi: 10.2463/mrms.cr.2016-0090. Epub 2017 Jan 13.

Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan

Mitsuhiro Tozaki  1 , Seigo Nakamura  2 , Dai Kitagawa  3 , Takuji Iwase  3 , Rie Horii  4 , Futoshi Akiyama  4 , Masami Arai  5
Affiliations
Case Reports

Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan

Mitsuhiro Tozaki et al. Magn Reson Med Sci. .

Abstract

The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This case is significant and it verifies the importance of MRI screening in breast or ovarian cancer-free BRCA1/2 mutation carriers who do not exhibit positive mammographic or ultrasonographic findings.

Keywords: BRCA2; ductal carcinoma in situ; hereditary breast and ovarian cancer syndrome; magnetic resonance imaging.

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Conflict of interest statement

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Figures

Fig 1.
Fig 1.
Pedigree of a proband individual with a BRCA2 mutation. The arrow indicates outpatient (proband). E+ represents BRCA2 mutation positive. The numbers represent age and organs represent the site of cancer origin. Roman numerals on the left edge represent generations. Squares, males; circles, females; oblique line, deceased. Open circle is a mutation carrier with no onset of cancers.
Fig 2.
Fig 2.
No abnormal findings were detected on these bilateral mediolateral oblique (MLO) (A) and craniocaudal (CC) (B) mammograms.
Fig 3.
Fig 3.
Ultrasonographic image of the right breast. There were no suspicious findings on the upper portion of the right breast.
Fig 4.
Fig 4.
(A, B) Magnetic Resonance (MR) image of both breasts. Background parenchymal enhancement (BPE) is minimal. Coronal first contrast-enhanced fat-suppressed T1-weighted MR image showed segmental non-mass lesions (arrows) located at the upper portion of the right breast. (C) MR image of the right breast. Sagittal contrast-enhanced fat-suppressed T1-weighted MR image showed branching ductal patterns (arrows) located at the upper portion of the right breast.
Fig 5.
Fig 5.
Second look ultrasonographic image of the right breast. There was an irregular-shaped hypoechoic area with ductal dilation (arrows) on the upper portion of the right breast.
Fig 6.
Fig 6.
Hematoxylin and eosin staining sections showed ductal carcinoma in situ (DCIS), micropapillary type, intermediate grade nuclei (NG2).
See this image and copyright information in PMC

References

    1. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266:66–71. - PubMed
    1. Ikeda N, Miyoshi Y, Yoneda K, et al. Frequency of BRCA1 and BRCA2 germline mutations in Japanese breast cancer families. Int J Cancer 2001; 91:83–88. - PubMed
    1. American College of Radiology Breast imaging reporting and data system (BI-RADS). 5th edn Reston, VA; 2013.
    1. Sugano K, Nakamura S, Ando J, et al. Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. Cancer Sci 2008; 99:1967–1976. - PMC - PubMed
    1. Nakamura S, Takahashi M, Tozaki M, et al. Prevalence and differentiation of hereditary breast and ovarian cancers in Japan. Breast Cancer 2015; 22:462–468. - PubMed

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