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Review
. 2016 Nov;23(6):7-24.
doi: 10.21315/mjms2016.23.6.2. Epub 2016 Dec 7.

Adiponectin, Leptin and Objectively Measured Physical Activity in Adults: A Narrative Review

Ali Nurnazahiah  1 , Pei Lin Lua  1 , Mohd Razif Shahril  1
Affiliations
Review

Adiponectin, Leptin and Objectively Measured Physical Activity in Adults: A Narrative Review

Ali Nurnazahiah et al. Malays J Med Sci. 2016 Nov.

Abstract

The objective of this study was to compile and analyse existing scientific evidences reporting the effects of objectively measured physical activity on the levels of adiponectin and leptin. Articles related to the effects of objectively measured physical activity on the levels of adiponectin and leptin were searched from the Medline and PubMed databases. The search was limited to 'objectively measured' physical activity, and studies that did not objectively measure the physical activity were excluded. Only English articles were included in the search and review. A total of 18 articles encompassing 2,026 respondents met the inclusion criteria. The eligible articles included all forms of evidence (e.g., cross-sectional and intervention). Seventeen and 11 studies showed the effects of objectively measured physical activity on adiponectin and leptin, respectively. Five and four cross-sectional studies showed the effects of objectively measured physical activity on adiponectin and leptin, respectively. Two out of five studies showed a weak to moderate positive association between adiponectin and objectively measured physical activity, while three out of four studies showed a weak to moderate inverse association between leptin and objectively measured physical activity. For intervention studies, six out of 12 studies involving adiponectin and five out of seven studies involving leptin showed a significant effect between the proteins and objectively measured physical activity. However, a definitive conclusion could not be drawn due to several methodological flaws in the existing articles and the acute lack of additional research in this area. In conclusion, the existing evidences are encouraging but yet not compelling. Hence, further well-designed large trials are needed before the effectiveness of objectively measured physical activity in elevating adiponectin levels and in decreasing leptin levels could be strongly confirmed.

Keywords: adiponectin; adults; cross-sectional studies; intervention study; leptin; physical activity.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
The flow in the literature search process
Figure 2
Figure 2
Relationship between physical activity, adipose tissue and adipokines (adiponectin and leptin)
See this image and copyright information in PMC

References

    1. Bauman AE, Reis RS, Sallis JF, et al. Correlates of physical activity: why are some people physically active and others not? Lancet. 2012;380:258–271. http://dx.doi.org/10.1016/S0140-6736(12)60735-1. - DOI - PubMed
    1. Pate RR, Pratt M, Blair SN, et al. Public health and prevention and the American College of Sports Medicine. JAMA. 1995;273:402–407. http://dx.doi.org/10.1001/jama.1995.03520290054029. - DOI - PubMed
    1. Lynch BM, Dunstan DW, Healy GN, et al. Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006) Cancer Causes Control. 2010;21:283–288. http://dx.doi.org/10.1007/s10552-009-9460-6. - DOI - PubMed
    1. Balboa-Castillo T, León-Muñoz LM, Graciani A, et al. Longitudinal association of physical activity and sedentary behavior during leisure time with health-related quality of life in community-dwelling older adults. Health Qual Life Outcomes. 2011;9:47. http://dx.doi.org/10.1186/1477-7525-9-47. - DOI - PMC - PubMed
    1. Paxton RJ, Jones LW, Rosoff PM, et al. Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers. Psychooncology. 2010;19:997–1003. http://dx.doi.org/10.1002/pon.1654. - DOI - PMC - PubMed

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