Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Jan 9:3:16104.
doi: 10.1038/cddiscovery.2016.104. eCollection 2017.

Long noncoding RNA: noncoding and not coded

Debra Toiber  1 , Gabriel Leprivier  2 , Barak Rotblat  1
Affiliations
Editorial

Long noncoding RNA: noncoding and not coded

Debra Toiber et al. Cell Death Discov. .

Erratum in

No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Hierarchy of lncRNA evolution linked to increase complexity of gene regulation. (a) the spatio-temporal regulation of the extent and strength of gene transcription is regulated by the gene’s promoter and chromatin state. (b) an adjacent promoter can add another layer of regulation to increase the tightness of the signal by the promoter activity directly and/or by the transcript arising for such a promoter (cis function). (c) the long noncoding transcript may bind proteins to further increase the complexity of regulation of the adjacent protein-coding gene (cis function). (d) the transcript may acquire trans functions such as binding to proteins and regulating their activity, sponging microRNA or binding to chromatin at distal locations.
See this image and copyright information in PMC

References

    1. Necsulea A et al. Nature 2014; 505: 635–640. - PubMed
    1. Tsai M-C et al. Science 2010; 329: 689–693. - PMC - PubMed
    1. Khalil AM et al. Proc Natl Acad Sci USA 2009; 106: 11667–11672. - PMC - PubMed
    1. Wang KC, Chang HY. Mol Cell 2011; 43: 904–914. - PMC - PubMed
    1. Xue Z et al. Mol Cell 2016; 64: 1–14. - PubMed

Publication types

LinkOut - more resources