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. 2017 Jan 16:7:40429.
doi: 10.1038/srep40429.

Ultrasound prediction of abnormal infant development in hypertensive pregnant women in the second and third trimester

Guofang Shen  1 , Yajuan Huang  2 , Lixin Jiang  1 , Jinghong Gu  2 , Yaxin Wang  1 , Bing Hu  1
Affiliations

Ultrasound prediction of abnormal infant development in hypertensive pregnant women in the second and third trimester

Guofang Shen et al. Sci Rep. .

Abstract

The objective was to assess the sensitivities and accuracies of Doppler ultrasound parameters in the second and third trimester of hypertensive pregnancies in determining perinatal outcomes. 1,054 pregnancies were retrospectively categorized into three groups (healthy pregnancies (HP, n = 988), pregnancies of hypertensive women (HypP, n = 30) and high-risk hypertension pregnancies (HRHypP, n = 36), depending on gestational hypertension as well as fetal birth weights and pregnancy outcomes. Systolic/diastolic ratio (S/D), resistance index (RI), pulsatility index (PI) of the bilateral uterine artery, umbilical artery and vein as well as venous flow velocity data were monitored by Doppler ultrasound. At 20-27 and 28-32 gestational weeks, uterine artery PIs and RIs were significantly higher in the HRHypP group than in the HP and HypP patients. At gestational weeks 20-27 and 28-32 left plus right PI data with cut-off values of 2.35 and 1.73 indicated a risk of stillbirth, premature pregnancy termination and a birth weight of less than 2,500 g with sensitivities of 94.4% and 93.1% as well as specificities of 95.2% and 90.1%, respectively.

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Figures

Figure 1
Figure 1. Flow chart of the study.
Figure 2
Figure 2. Representative Doppler ultrasound images at ~23 weeks of pregnancy.
(a) Normal pregnancy umbilical artery. (b) Normal pregnancy umbilical vein. (c) HRHypP (umbilical artery with fetal death. (d) HRHypP umbilical vein with fetal death. (e) Normal pregnancy right uterine artery. (f) Normal pregnancy left uterine artery. (g) HRHypP right uterine artery with fetal death. (h) HRHypP uterine artery with fetal death.
Figure 3
Figure 3. Sensitivity and specificity of ultrasound prediction indices in gestational weeks 20–27 in ROC curves.
Figure 4
Figure 4. Sensitivity and specificity of ultrasound prediction indices in gestational weeks 28–32 in ROC curves.
See this image and copyright information in PMC

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