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Review
. 2017 Sep;18(3):347-354.
doi: 10.1007/s11154-017-9406-3.

Sunshine vitamin and thyroid

Immacolata Cristina Nettore  1 , Luigi Albano  2 , Paola Ungaro  3 , Annamaria Colao  1 , Paolo Emidio Macchia  4
Affiliations
Review

Sunshine vitamin and thyroid

Immacolata Cristina Nettore et al. Rev Endocr Metab Disord. 2017 Sep.

Abstract

Vitamin D exerts its canonical roles on the musculoskeletal system and in the calcium/phosphorus homeostasis. In the last years, increasing evidences suggested several extra-skeletal actions of this hormone, indicating that vitamin D may produce effects in almost all the body tissues. These are mediated by the presence of vitamin D receptor (VDR) and thanks to the presence of the 1-α-hydroxylase, the protein that converts the 25-hydroxyvitamin (calcidiol) to the active form 1,25-dihydroxyvitamin (calcitriol). Several studies evaluated the possible role of vitamin D in the pathogenesis of thyroid diseases, and this review will focus on the available data of the literature evaluating the association between vitamin D and thyroid function, vitamin D and autoimmune thyroid diseases, including Hashimoto's thyroiditis, Graves' disease and post-partum thyroiditis, and vitamin D and thyroid cancer.

Keywords: Graves’ disease; Hashimoto’s thyroiditis; Post-partum thyroiditis; Thyroid cancer; Vitamin D.

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Conflict of interest statement

All the authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. The authors declare no support from any commercial organization for the submitted work.

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