What Have We Learned from SH2 Domains?

Abstract

SH2 domains first shed light on the key role of modular binding domains in cell signaling. Much of what we now know about the logic and design principles underlying cell signaling mechanisms, and how such mechanisms might have evolved, can be traced back to early work on SH2 domains. Here we briefly outline several key concepts that emerged from such studies.

Keywords: Cell signaling; Modular binding domains; Tyrosine phosphorylation.