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Comment
. 2017 Feb;158(2):185-186.
doi: 10.1097/j.pain.0000000000000726.

Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors

David Borsook  1
Affiliations
Comment

Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors

David Borsook. Pain. 2017 Feb.
No abstract available

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Comment on

  • Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?
    Nees F, Becker S, Millenet S, Banaschewski T, Poustka L, Bokde A, Bromberg U, Büchel C, Conrod PJ, Desrivières S, Frouin V, Gallinat J, Garavan H, Heinz A, Ittermann B, Martinot JL, Papadopoulos Orfanos D, Paus T, Smolka MN, Walter H, Whelan R, Schumann G, Flor H; IMAGEN consortium. Nees F, et al. Pain. 2017 Feb;158(2):212-219. doi: 10.1097/j.pain.0000000000000720. Pain. 2017. PMID: 28092323

References

    1. Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003;106:49–57. - PubMed
    1. Baliki MN, Petre B, Torbey S, et al. Corticostriatal functional connectivity predicts transition to chronic back pain. Nature neuroscience. 2012;15:1117–1119. - PMC - PubMed
    1. Balleine BW, Delgado MR, Hikosaka O. The role of the dorsal striatum in reward and decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27:8161–8165. - PMC - PubMed
    1. Bannister K, Dickenson AH. Opioid hyperalgesia. Current opinion in supportive and palliative care. 2010;4:1–5. - PubMed
    1. Becerra L, Breiter HC, Wise R, Gonzalez RG, Borsook D. Reward circuitry activation by noxious thermal stimuli. Neuron. 2001;32:927–946. - PubMed

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