Wnt/β-catenin signaling activates nephronectin expression in osteoblasts

Mikiko Ikehata¹, Atsushi Yamada², Naoko Morimura³, Masakatsu Itose⁴, Tetsuo Suzawa⁵, Tatsuo Shirota⁶, Daichi Chikazu⁷, Ryutaro Kamijo⁵

Affiliations

¹ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
² Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan. Electronic address: yamadaa@dent.showa-u.ac.jp.
³ Department of Integrative Physiology, Shiga University of Medical Science, Shiga, Japan.
⁴ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
⁵ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
⁶ Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
⁷ Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

PMID: 28093227
DOI: 10.1016/j.bbrc.2017.01.053

Wnt/β-catenin signaling activates nephronectin expression in osteoblasts

Mikiko Ikehata et al. Biochem Biophys Res Commun. 2017.

. 2017 Mar 4;484(2):231-234.

doi: 10.1016/j.bbrc.2017.01.053. Epub 2017 Jan 16.

Authors

Mikiko Ikehata¹, Atsushi Yamada², Naoko Morimura³, Masakatsu Itose⁴, Tetsuo Suzawa⁵, Tatsuo Shirota⁶, Daichi Chikazu⁷, Ryutaro Kamijo⁵

Affiliations

¹ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
² Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan. Electronic address: yamadaa@dent.showa-u.ac.jp.
³ Department of Integrative Physiology, Shiga University of Medical Science, Shiga, Japan.
⁴ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
⁵ Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
⁶ Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
⁷ Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

PMID: 28093227
DOI: 10.1016/j.bbrc.2017.01.053

Abstract

Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles as an adhesion molecule in the development and functions of various organs and tissues, such as the kidneys and bone. In the present study, we found that Wnt3a strongly enhanced Npnt mRNA expression in osteoblast-like MC3T3-E1 cells, while it also induced an increase in Npnt gene expression in both time- and dose-dependent manners via the Wnt/β-catenin signaling pathway. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression.

Keywords: Nephronectin; Wnt3a; β-catenin.

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Wnt/β-catenin signaling activates nephronectin expression in osteoblasts

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Wnt/β-catenin signaling activates nephronectin expression in osteoblasts

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Affiliations

Abstract

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