Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound
- PMID: 28094
Item in Clipboard
Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound
Arch Int Pharmacodyn Ther.
1978 Apr.
Abstract
Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. In vivo it is a powerful antagonist of bronchospasm induced by serotonin and by histamine; it has no anticholinergic effects and does not affect blood pressure in spontaneously hypertensive rats. These antiserotonin properties of oxatomide may contribute significantly to its anti-allergic activity.
Similar articles
-
[Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators].Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409. Nihon Yakurigaku Zasshi. 1983. PMID: 6138301 Japanese.
-
[Effect of 1-[3-[4-(diphenylmethyl)-1-priperazinyl]-propyl]-1,3-dihydro-2H-benzimidazol-2- one (oxatomide) on contraction of canine bronchial muscle].Nihon Heikatsukin Gakkai Zasshi. 1983 Feb;19(1):47-54. Nihon Heikatsukin Gakkai Zasshi. 1983. PMID: 6141314 Japanese.
-
Further studies on lidoflazine (R-7904).Arzneimittelforschung. 1968 Sep;18(9):1209-12. Arzneimittelforschung. 1968. PMID: 4387885 No abstract available.
-
Pharmacology of the new H1-receptor antagonist setastine hydrochloride.Arzneimittelforschung. 1990 Dec;40(12):1340-5. Arzneimittelforschung. 1990. PMID: 1982751
-
Animal pharmacology of the selective histamine H1-receptor antagonist tazifylline.Arzneimittelforschung. 1986 Apr;36(4):695-702. Arzneimittelforschung. 1986. PMID: 2424463
Cited by
-
In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634.Agents Actions. 1981 Jul;11(4):345-51. doi: 10.1007/BF01982470. Agents Actions. 1981. PMID: 6169263
-
Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.Drugs. 1984 Mar;27(3):210-31. doi: 10.2165/00003495-198427030-00003. Drugs. 1984. PMID: 6200290 Review.
-
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.Agents Actions. 1989 Aug;28(1-2):53-61. doi: 10.1007/BF02022980. Agents Actions. 1989. PMID: 2571244
-
Ro 21-7634, a new antiallergic agent with potent oral activity.Agents Actions. 1981 Jul;11(4):339-44. doi: 10.1007/BF01982469. Agents Actions. 1981. PMID: 7025596
-
Pulmonary vascular actions of the antihistamine oxatomide during hypoxia.Agents Actions. 1980 Jun;10(3):207-12. doi: 10.1007/BF02025937. Agents Actions. 1980. PMID: 6157318