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. 1978 Apr;232(2):217-20.

Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound

J M Van Nueten, R Xhonneux, P A Janssen
  • PMID: 28094

Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound

J M Van Nueten et al. Arch Int Pharmacodyn Ther. 1978 Apr.

Abstract

Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. In vivo it is a powerful antagonist of bronchospasm induced by serotonin and by histamine; it has no anticholinergic effects and does not affect blood pressure in spontaneously hypertensive rats. These antiserotonin properties of oxatomide may contribute significantly to its anti-allergic activity.

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