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Comment
. 2017 Jan 31;114(5):803-804.
doi: 10.1073/pnas.1620082114. Epub 2017 Jan 17.

Combating Parkinson's disease-associated toxicity by modulating proteostasis

Yangshin Park  1   2   3 , Quyen Q Hoang  4   2   3
Affiliations
Comment

Combating Parkinson's disease-associated toxicity by modulating proteostasis

Yangshin Park et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Cartoon presentation of Nrf2 rescuing LRRK2- and α-synuclein (α-Syn)–induced toxicity as described by Skibinski et al. (15). Nrf2 activation leading to the transcription of stress-inducible genes resulted in a reduction of toxic levels of α-synuclein and sequestration of toxic LRRK2 mutants into inclusion bodies.
See this image and copyright information in PMC

Comment on

References

    1. Prince M, et al. World Alzheimer Report 2015. Alzheimer’s Disease International; London: 2015. The global impact of dementia; pp. 1–82.
    1. Krstic D, Knuesel I. Deciphering the mechanism underlying late-onset Alzheimer disease. Nat Rev Neurol. 2013;9(1):25–34. - PubMed
    1. Trinh J, Farrer M. Advances in the genetics of Parkinson disease. Nat Rev Neurol. 2013;9(8):445–454. - PubMed
    1. Labbadia J, Morimoto RI. Huntington’s disease: Underlying molecular mechanisms and emerging concepts. Trends Biochem Sci. 2013;38(8):378–385. - PMC - PubMed
    1. Robberecht W, Philips T. The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci. 2013;14(4):248–264. - PubMed

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