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. 2016 Oct-Dec;32(4):476-482.
doi: 10.4103/0970-9185.194762.

The effect of pregabalin and s-ketamine in total knee arthroplasty patients: A randomized trial

Lajla Kadic  1 , Frank G van Haren  1 , Oliver Wilder-Smith  1 , Jorgen Bruhn  1 , Jacques J Driessen  1 , Maarten C de Waal Malefijt  2
Affiliations

The effect of pregabalin and s-ketamine in total knee arthroplasty patients: A randomized trial

Lajla Kadic et al. J Anaesthesiol Clin Pharmacol. 2016 Oct-Dec.

Abstract

Background and aims: Pain reduction is important for rehabilitation after total knee arthroplasty. Intra- and peri-articular infiltration with local anesthetics may be an alternative to commonly used locoregional techniques. Adding pregabalin orally and s-ketamine intravenously may further reduce postoperative pain.

Material and methods: This prospective, randomized, double-blind, placebo-controlled study compared two methods of perioperative analgesia. Control patients received a standardized multimodal postoperative analgesic regime of paracetamol, diclofenac, and piritramide-patient-controlled analgesia, including ropivacaine knee infiltration during surgery. The study group received pregabalin orally and s-ketamine intravenously as an additional medication to the standard multimodal regimen. The control group received placebo.

Results: The study group showed lower piritramide consumption during the first 24 h (P: 0.043), but with more side effects such as diplopia and dizziness.

Conclusion: Addition of pregabalin and s-ketamine resulted in lower piritramide consumption during the first 24 h postoperatively. However, more investigation on benefits versus side effects of this medication is required.

Keywords: pregabalin; s-ketamine; total knee arthroplasty.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
CONSORT flow diagram
Figure 2
Figure 2
NRS for days (D) 0–3 for ‘rest’ (R) and‘dynamic’ (D): mean with 95% confidence intervals. Results are presented for patients in the control group (black bars) and study group (white bars).
Figure 3
Figure 3
The knee flexion (degrees) on day one to three. Mean values with 95% confidence intervals. The results are for the patients in the control group (black bars), for the study group (white bars).
See this image and copyright information in PMC

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