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. 2016 Oct-Dec;32(4):492-496.
doi: 10.4103/0970-9185.168257.

Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy

Ghanshyam Yadav  1 , Gaurav Jain  1 , Abhishek Samprathi  1 , Annavi Baghel  2 , Dinesh Kumar Singh  1
Affiliations

Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy

Ghanshyam Yadav et al. J Anaesthesiol Clin Pharmacol. 2016 Oct-Dec.

Abstract

Background and aims: Poorly managed acute postoperative pain may result in prolonged morbidity. Various pharmacotherapies have targeted this, but research on an ideal preemptive analgesic continues, taking into account drug-related side effects. Considering the better tolerability profile of tapentadol, we assessed its role as a preemptive analgesic in the reduction of postoperative analgesic requirements, after laparoscopic cholecystectomy.

Material and methods: In a prospective-double-blinded fashion, sixty patients posted for above surgery, were randomized to receive tablet tapentadol 75 mg (Group A) or starch tablets (Group B) orally, an hour before induction of general anesthesia. Perioperative analgesic requirement, time to first analgesia, pain, and sedation score were compared for first 24 h during the postoperative period and analyzed by one-way analysis of variance test. A P < 0.05 was considered significant.

Results: Sixty patients were analyzed. The perioperative analgesic requirement was significantly lower in Group A. Verbal numerical score was significantly lower in Group A at the time point, immediately after shifting the patient to the postanesthesia care unit. Ramsay sedation scores were similar between the groups. No major side effects were observed except for nausea and vomiting in 26 cases (10 in Group A, 16 in Group B).

Conclusion: Single preemptive oral dose of tapentadol (75 mg) is effective in reducing perioperative analgesic requirements and acute postoperative pain, without added side effects. It could be an appropriate preemptive analgesic, subjected to future trials concentrating upon its dose-response effects.

Keywords: Analgesia; cholecystectomy; tapentadol.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of patients studied
Figure 2
Figure 2
Comparison of postoperative pain scores between the groups. Data expressed as mean ± standard deviation P < 0.05 considered significant (*P < 0.05, **P < 0.001). Group A = Tapentadol group, Group B = Control group, VNS = Verbal numerical score
Figure 3
Figure 3
Comparison of postoperative sedation scores between the groups. Data expressed as mean ± standard deviation. Group A = Tapentadol group, Group B = Control group, RSS = Ramsay sedation score
See this image and copyright information in PMC

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