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. 2017 Feb 13;56(8):2118-2122.
doi: 10.1002/anie.201611207. Epub 2017 Jan 18.

AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents

Gábor Nagy  1   2 , Dezső Szikra  1   2 , György Trencsényi  1   2 , Anikó Fekete  2 , Ildikó Garai  1 , Arianna M Giani  3 , Roberto Negri  3 , Norberto Masciocchi  4 , Alessandro Maiocchi  5 , Fulvio Uggeri  5 , Imre Tóth  6 , Silvio Aime  7 , Giovanni B Giovenzana  3   8 , Zsolt Baranyai  5   6
Affiliations

AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents

Gábor Nagy et al. Angew Chem Int Ed Engl. .

Abstract

Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.

Keywords: PET; kinetics; radiopharmaceuticals; scandium; thermodynamics.

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