Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb 20;56(9):2459-2463.
doi: 10.1002/anie.201611625. Epub 2017 Jan 18.

Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes

Fu-Min Liao  1 , Zhong-Yan Cao  1 , Jin-Sheng Yu  1 , Jian Zhou  1   2
Affiliations

Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes

Fu-Min Liao et al. Angew Chem Int Ed Engl. .

Abstract

We report a highly stereoselective synthesis of all-carbon or fluorinated tetrasubstituted alkenes from diazo reagents and fluorinated enol silyl ethers, using C-F bond as a synthetic handle. Cationic AuI catalysis plays a key role in this reaction. Remarkable fluorine effects on the reactivity and selectivity was also observed.

Keywords: coupling reactions; diazo reagents; fluorine effects; gold catalysis; olefination.

PubMed Disclaimer

Publication types

LinkOut - more resources