Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb;23(2):276-279.
doi: 10.3201/2302.161095.

Changing Epidemiology of Hepatitis A and Hepatitis E Viruses in China, 1990-2014

Changing Epidemiology of Hepatitis A and Hepatitis E Viruses in China, 1990-2014

Xiang Ren et al. Emerg Infect Dis. 2017 Feb.

Erratum in

  • Correction: Vol. 23, No. 2.
    [No authors listed] [No authors listed] Emerg Infect Dis. 2017 Mar;23(3):560. doi: 10.3201/eid2303.C22303. Emerg Infect Dis. 2017. PMID: 31305617 Free PMC article.

Abstract

We compared the epidemiology of hepatitis A and hepatitis E cases in China from 1990-2014 to better inform policy and prevention efforts. The incidence of hepatitis A cases declined dramatically, while hepatitis E incidence increased. During 2004-2014, hepatitis E mortality rates surpassed those of hepatitis A.

Keywords: China; epidemiology; hepatitis A; hepatitis E; vaccination; vaccine; viruses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Annual incidence (solid lines) and mortality rates (dashed lines) of notified hepatitis A (blue) and E (red) cases in China, 1990-2014. The inset shows an enlarged view of rates during 2009–2014. EPI, Expanded Program on Immunization; VCP, virus-like particle.
Figure 2
Figure 2
Age distribution of patients with reported cases of A) hepatitis A (blue, male patients; green, female patients) and B) hepatitis E (red, male patients; purple, female patients) in China for 1990–1999, 2000–2009, and 2010–2014. Incidence and mortality rates were calculated in 10-year age groups for the 3 periods. For each color, the darker shade represents incidence and the lighter shade represents mortality rate.

References

    1. André FE. Universal mass vaccination against hepatitis A. Curr Top Microbiol Immunol. 2006;304:95–114. 10.1007/3-540-36583-4_6 - DOI - PubMed
    1. Van Damme P, Banatvala J, Fay O, Iwarson S, McMahon B, Van Herck K, et al.; International Consensus Group on Hepatitis A Virus Immunity. Hepatitis A booster vaccination: is there a need? Lancet. 2003;362:1065–71. 10.1016/S0140-6736(03)14418-2 - DOI - PubMed
    1. Cui F, Hadler SC, Zheng H, Wang F, Zhenhua W, Yuansheng H, et al. Hepatitis A surveillance and vaccine use in China from 1990 through 2007. J. Epidemiol.. 2009;19:189–95. - PMC - PubMed
    1. Teo CG. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol Infect. 2012;140:767–87. 10.1017/S0950268811002925 - DOI - PubMed
    1. Zhang J, Zhang XF, Huang SJ, Wu T, Hu YM, Wang ZZ, et al. Long-term efficacy of a hepatitis E vaccine. N Engl J Med. 2015;372:914–22. 10.1056/NEJMoa1406011 - DOI - PubMed

Publication types

LinkOut - more resources