Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb;23(2):353-356.
doi: 10.3201/eid2302.161094.

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France

Sebastien Lhomme, Laurent Bardiaux, Florence Abravanel, Pierre Gallian, Nassim Kamar, Jacques Izopet

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France

Sebastien Lhomme et al. Emerg Infect Dis. 2017 Feb.

Abstract

The rate of transfusion-transmitted hepatitis E virus (HEV) in transplant recipients is unknown. We identified 60 HEV-positive solid organ transplant patients and retrospectively assessed their blood transfusions for HEV. Seven of 60 patients received transfusions; 3 received HEV-positive blood products. Transfusion is not the major route of infection in this population.

Keywords: France; blood transfusion; hepatitis E; hepatitis E virus; solid organ transplant patients; viruses.

PubMed Disclaimer

Figures

Figure
Figure
Phylogenetic tree of hepatitis E virus (HEV) isolates from 3 HEV-positive blood donors and 3 solid organ transplant recipients (shown in bold), France, compared with reference isolates. The tree was constructed by using partial open reading frame 2 sequences (348 nt). HEV genotypes are indicated at right. A confirmed case of transfusion-transmitted HEV infection requires evidence of infection in the recipient and donor and that the nucleotide sequences of these isolates be identical. The isolates from France were deposited in GenBank under accession nos. KX452928–KX452935; accession numbers, sources, and location of isolation for other isolates are indicated. Scale bar indicates nucleotide substitutions per site.
See this image and copyright information in PMC

References

    1. Kamar N, Dalton HR, Abravanel F, Izopet J. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27:116–38. 10.1128/CMR.00057-13 - DOI - PMC - PubMed
    1. Boxall E, Herborn A, Kochethu G, Pratt G, Adams D, Ijaz S, et al. Transfusion-transmitted hepatitis E in a ‘nonhyperendemic’ country. Transfus Med. 2006;16:79–83. 10.1111/j.1365-3148.2006.00652.x - DOI - PubMed
    1. Mahajan R, Collier MG, Kamili S, Drobeniuc J, Cuevas-Mota J, Garfein RS, et al. Hepatitis E virus among persons who inject drugs, San Diego, California, USA, 2009-2010. Emerg Infect Dis. 2013;19:1664–6. 10.3201/eid1910.130630 - DOI - PMC - PubMed
    1. Mezochow AK, Henry R, Blumberg EA, Kotton CN. Transfusion transmitted infections in solid organ transplantation. Am J Transplant. 2015;15:547–54. 10.1111/ajt.13006 - DOI - PubMed
    1. Legrand-Abravanel F, Kamar N, Sandres-Saune K, Garrouste C, Dubois M, Mansuy JM, et al. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J Infect Dis. 2010;202:835–44. 10.1086/655899 - DOI - PubMed