Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 Feb;23(2):308-311.
doi: 10.3201/eid2302.160505.

Risk Factors for Disseminated Coccidioidomycosis, United States

Camila D Odio, Beatriz E Marciano, John N Galgiani, Steven M Holland
Meta-Analysis

Risk Factors for Disseminated Coccidioidomycosis, United States

Camila D Odio et al. Emerg Infect Dis. 2017 Feb.

Abstract

Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.

Keywords: Coccidioides; IL-12/IFN-γ; Immunodeficiency; United States; coccidioidomycosis; disseminated coccidioidomycosis; ethnicity; fungi; immunosuppression; interferon; interleukin-12; race.

PubMed Disclaimer

References

    1. Centers for Disease Control and Prevention (CDC). Increase in reported coccidioidomycosis—United States, 1998-2011. MMWR Morb Mortal Wkly Rep. 2013;62:217–21. - PMC - PubMed
    1. Valdivia L, Nix D, Wright M, Lindberg E, Fagan T, Lieberman D, et al. Coccidioidomycosis as a common cause of community-acquired pneumonia. Emerg Infect Dis. 2006;12:958–62. 10.3201/eid1206.060028 - DOI - PMC - PubMed
    1. Ampel NM, Giblin A, Mourani JP, Galgiani JN. Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. Clin Infect Dis. 2009;48:172–8. 10.1086/595687 - DOI - PubMed
    1. Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Geertsma F, Hoover SE, et al. 2016 Infectious Diseases Society of America (IDSA) clinical practice guideline for the treatment of coccidioidomycosis. Clin Infect Dis. 2016;63:e112–46. 10.1093/cid/ciw360 - DOI - PubMed
    1. Crum NF, Ballon-Landa G. Coccidioidomycosis in pregnancy: case report and review of the literature. Am J Med. 2006;119:993.e11–7. 10.1016/j.amjmed.2006.04.022 - DOI - PubMed

Publication types

MeSH terms