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Review
. 2017 Feb;45(2):305-310.
doi: 10.1097/CCM.0000000000002182.

The Brain and Hypothermia-From Aristotle to Targeted Temperature Management

Patrick M Kochanek  1 , Travis C Jackson
Affiliations
Review

The Brain and Hypothermia-From Aristotle to Targeted Temperature Management

Patrick M Kochanek et al. Crit Care Med. 2017 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Effect of ±1°C on brain function, biochemistry, and the injury response. (Left Table/Blue font) Selected studies supporting that 36°C activates neuroprotective pathways associated with targeted temperature management (TTM) or ultra-mild hypothermia (UMH) (28, 33, 35, 51-53). (Right Table/Red font) Selected studies supporting that 38°C activates detrimental pathways associated with mild (sub-febrile) hyperthermia. TTM/UMH holds promise as a potent and safe therapy to block detrimental pathways engaged on the right while simultaneously activating direct neuroprotective signaling pathways such as RBM3 (50, 53-57).
Figure 2
Figure 2
Future and or ongoing areas of investigation for therapeutic hypothermia in neurocritical care including traumatic brain injury, cardiac arrest in children and adults, perinatal asphyxia, spinal cord injury, stroke, refractory status epilepticus, and trauma induced exsanguination cardiac arrest. RCTs = randomized controlled trials, TTM = targeted temperature management, HIE = hypoxic ischemic encephalopathy, EPR = emergency preservation and resuscitation, CAT = cardiac arrest from trauma.
See this image and copyright information in PMC

References

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