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. 2017 Feb 1;139(4):1388-1391.
doi: 10.1021/jacs.6b11234. Epub 2017 Jan 23.

Chemo- and Regioselective Distal Heteroaryl ipso-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes

Zhen Wu  1 , Dongping Wang  1 , Yuan Liu  1 , Leitao Huan  1 , Chen Zhu  1
Affiliations

Chemo- and Regioselective Distal Heteroaryl ipso-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes

Zhen Wu et al. J Am Chem Soc. .

Abstract

Herein we report a novel, general protocol for distal heteroaryl ipso-migration and its application to the elusive heteroarylation of unactivated alkenes. A set of nitrogen-containing heteroaryl groups showcase the migratory aptitude. This reaction provides a variety of fluoroalkyl functionalized heteroarenes under mild reaction conditions. This is the first report of a difunctionalization of unactivated alkenes with distal heteroaryl migration.

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