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. 2016 Nov-Dec;91(6):738-741.
doi: 10.1590/abd1806-4841.20164730.

Angiosarcoma in HIV-negative patients is not associated with HHV-8

João Avancini  1 , José Antonio Sanches  1 , Andre Pires Zanata Cherubim  1 , Renato Pazzini  1 , Cristina Mendes de Oliveira  1 , Laura Masami Sumita  1 , Neusa Yuriko Sakai Valente  1 , Claudio Sergio Pannuti  1 , Cyro Festa Neto  1
Affiliations

Angiosarcoma in HIV-negative patients is not associated with HHV-8

João Avancini et al. An Bras Dermatol. 2016 Nov-Dec.

Abstract

Background:: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.

Objective:: To investigate the relationship between the presence of HHV-8 and angiosarcoma.

Methods:: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.

Results:: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.

Conclusion:: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Angiosarcoma lesion in a patient with chronic lymphedema
See this image and copyright information in PMC

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