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Review
. 2016 Oct-Dec;28(4):472-482.
doi: 10.5935/0103-507X.20160080.

Use of biomarkers in pediatric sepsis: literature review

[Article in Portuguese, English]
Vanessa Soares Lanziotti  1   2 , Pedro Póvoa  3   4 , Márcio Soares  1 , José Roberto Lapa E Silva  2 , Arnaldo Prata Barbosa  1   4 , Jorge Ibrain Figueira Salluh  1
Affiliations
Review

Use of biomarkers in pediatric sepsis: literature review

[Article in Portuguese, English]
Vanessa Soares Lanziotti et al. Rev Bras Ter Intensiva. 2016 Oct-Dec.

Abstract
in English, Portuguese

Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

A despeito dos avanços nos últimos anos, a sepse ainda é uma das principais causas de internação e mortalidade em lactentes e crianças. A presença de biomarcadores na resposta a um insulto infeccioso resulta em seu uso na triagem, no diagnóstico, no prognóstico (estratificação de risco), na monitorização da resposta terapêutica e no uso racional de antibióticos (duração adequada, por exemplo). Os estudos sobre biomarcadores na sepse em crianças são ainda relativamente escassos. Esta revisão aborda o uso de biomarcadores na sepse em pacientes pediátricos, com ênfase em proteína C-reativa, procalcitonina, interleucinas 6, 8 e 18, gelatinase dos neutrófilos humanos e proadrenomedulina, que podem ser úteis na abordagem da sepse pediátrica.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Biomarkers in pediatric sepsis. CRP - C-reactive protein; PCT - procalcitonin; IL-6 - interleukin 6; IL-8 - interleukin 8; NGAL - human neutrophil gelatinase.
See this image and copyright information in PMC

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