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Comment
. 2017 Jan 17;46(1):13-14.
doi: 10.1016/j.immuni.2016.12.020.

T Cells Take on Zika Virus

Heather D Hickman  1 , Theodore C Pierson  2
Affiliations
Comment

T Cells Take on Zika Virus

Heather D Hickman et al. Immunity. .

Abstract

Although CD8+ T cells provide protection against many viral infections, their role in Zika virus (ZIKV) immunity has not been extensively examined. In a recent issue of Cell Host & Microbe, Elong Ngono et al. (2017) define antigenic epitopes determining CD8+ T cell immunity in murine models of ZIKV infection.

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Figures

Figure 1.
Figure 1.. Location of Antigenic T Cell Epitopes in the ZIKV Polyprotein
The ZIKV genome encodes a single open reading frame that is processed into ten individual proteins by host and viral proteases. Viral structural proteins are depicted in this schematic in blue, whereas nonstructural proteins are in gray. Dots below each protein indicate an individual T cell epitope derived from that protein in C57BL/6 mice. The green dot represents the immunodominant T cell epitope.
See this image and copyright information in PMC

Comment on

References

    1. Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng’ang’a D, Nanayakkara O, et al. (2016). Science 353, 1129–1132. - PMC - PubMed
    1. Elong Ngono A, Vizcarra EA, Tang WW, Sheets N, Joo Y, Kim K, Gorman MJ, Diamond MS, and Shresta S (2017). Cell Host Microbe 21. Published online January 11, 2017. - PMC - PubMed
    1. Hazin AN, Poretti A, Turchi Martelli CM, Huisman TA, Di Cavalcanti Souza Cruz D, Tenorio M, van der Linden A, Pena LJ, Brito C, Gil LH, et al.; Microcephaly Epidemic Research Group (2016). N. Engl. J. Med 374, 2193–2195. - PubMed
    1. Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, and Perreault C (2016). Nat. Commun 7, 10238. - PMC - PubMed
    1. Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, and Diamond MS (2016). Cell Host Microbe 19, 720–730. - PMC - PubMed