Satb1: Restraining PD1 and T Cell Exhaustion

Briana G Nixon¹, Ming O Li²

Affiliations

¹ Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: lim@mskcc.org.

PMID: 28099863
DOI: 10.1016/j.immuni.2017.01.002

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Satb1: Restraining PD1 and T Cell Exhaustion

Briana G Nixon et al. Immunity. 2017.

Free article

. 2017 Jan 17;46(1):3-5.

doi: 10.1016/j.immuni.2017.01.002.

Authors

Briana G Nixon¹, Ming O Li²

Affiliations

¹ Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: lim@mskcc.org.

PMID: 28099863
DOI: 10.1016/j.immuni.2017.01.002

Abstract

Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.

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SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Stephen TL, Payne KK, Chaurio RA, Allegrezza MJ, Zhu H, Perez-Sanz J, Perales-Puchalt A, Nguyen JM, Vara-Ailor AE, Eruslanov EB, Borowsky ME, Zhang R, Laufer TM, Conejo-Garcia JR. Stephen TL, et al. Immunity. 2017 Jan 17;46(1):51-64. doi: 10.1016/j.immuni.2016.12.015. Immunity. 2017. PMID: 28099864 Free PMC article.

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Satb1: Restraining PD1 and T Cell Exhaustion

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Satb1: Restraining PD1 and T Cell Exhaustion

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Abstract

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