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Editorial
. 2017 Feb 14;8(7):10777-10778.
doi: 10.18632/oncotarget.14650.

Oxidative stress in neurodegenerative disease: causation or association?

Jeremy M Van Raamsdonk  1 , Irving E Vega  2 , Patrik Brundin  3
Affiliations
Editorial

Oxidative stress in neurodegenerative disease: causation or association?

Jeremy M Van Raamsdonk et al. Oncotarget. .
No abstract available

Keywords: Alzheimer’s disease; Huntington’s disease; Neuroscience; Parkinson’s disease; aging; oxidative stress.

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Figures

Figure 1
Figure 1. Causation and association models for the role of oxidative stress in neurodegenerative disease
If oxidative stress contributes to disease pathogenesis (top) then increasing oxidative stress through activity-lowering single nucleotide polymorphisms in antioxidant genes, or decreasing oxidative stress through treatment with antioxidants should affect the onset and or severity of the disease. If oxidative stress is associated with disease (bottom) then the disease gene, or environmental factors causing the disease, give rise to oxidative stress and disease symptoms independently.
See this image and copyright information in PMC

References

    1. Machiela E, et al. Neurobiology of disease. 2016;96:1–11. - PubMed
    1. Van Raamsdonk JM, et al. PLoS Genet. 2009;5:e1000361. - PMC - PubMed
    1. Van Raamsdonk JM, et al. Proc Natl Acad Sci U S A. 2012;109:5785–5790. - PMC - PubMed
    1. Schaar CE, et al. PLoS Genet. 2015;11:e1004972. - PMC - PubMed
    1. Pohanka M. Current medicinal chemistry. 2014;21:356–364. - PubMed

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