Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan 6;10(1):2.
doi: 10.1186/s40413-016-0138-8. eCollection 2017.

Is allergic sensitization relevant in severe asthma? Which allergens may be culprit?

Carlo Lombardi  1 , Eleonora Savi  2 , Erminia Ridolo  3 , Giovanni Passalacqua  4 , Giorgio Walter Canonica  4
Affiliations
Review

Is allergic sensitization relevant in severe asthma? Which allergens may be culprit?

Carlo Lombardi et al. World Allergy Organ J. .

Abstract

Severe asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor. A detailed knowledge of the most harmful allergens is mandatory for an appropriate diagnostic and preventive approach.

Keywords: Allergens; Allergic sensitization; Atopy; Severe asthma.

PubMed Disclaimer

References

    1. Pearce N, Ait-Khaled N, Beasley R, et al. Worldwide trends in the prevalence of asthma symptoms: Phase III of the International Study of Asthma ans Allergies in Chilhood (ISAAC) Thorax. 2007;62:758–766. doi: 10.1136/thx.2006.070169. - DOI - PMC - PubMed
    1. Sembajwe G, Cifuentes M, Tak SW, et al. National income, self-reported wheezing and asthma diagnosis from the World Health Survey. Eur Respir J. 2010;35:279–286. doi: 10.1183/09031936.00027509. - DOI - PubMed
    1. Gibson GJ, Loddenkemper R, Lundba¨ B, Sibille Y. Respiratory health and disease in Europe: the new European Lung White Book. Eur Respir J. 2013;42:559–563. doi: 10.1183/09031936.00105513. - DOI - PubMed
    1. VV.AA. The 2016 update of the Global Strategy for Asthma Management and Prevention; http://ginasthma.org/2016-gina-report-global-strategy-for-asthma-managem...
    1. Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations:document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126:926–938. doi: 10.1016/j.jaci.2010.07.019. - DOI - PubMed

LinkOut - more resources