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. 2016 Dec 14;8(1):273-280.
doi: 10.1364/BOE.8.000273. eCollection 2017 Jan 1.

Investigation of terahertz radiation influence on rat glial cells

Mariia Borovkova  1 , Maria Serebriakova  2 , Viacheslav Fedorov  3 , Egor Sedykh  1 , Vladimir Vaks  4 , Alexander Lichutin  1 , Alina Salnikova  1 , Mikhail Khodzitsky  1
Affiliations

Investigation of terahertz radiation influence on rat glial cells

Mariia Borovkova et al. Biomed Opt Express. .

Abstract

We studied an influence of continuous terahertz (THz) radiation (0.12 - 0.18 THz, average power density of 3.2 mW/cm2) on a rat glial cell line. A dose-dependent cytotoxic effect of THz radiation is demonstrated. After 1 minute of THz radiation exposure a relative number of apoptotic cells increased in 1.5 times, after 3 minutes it doubled. This result confirms the concept of biological hazard of intense THz radiation. Diagnostic applications of THz radiation can be restricted by the radiation power density and exposure time.

Keywords: (170.0170) Medical optics and biotechnology; (170.3660) Light propagation in tissues.

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Figures

Fig. 1
Fig. 1
Gating tactics used for isolation of live cells and cells at different stages of apoptosis.
Fig. 2
Fig. 2
Experimental setup: THz radiation emitted by BWO is fed into horn antenna and collimated using TPX lens to obtain 20 mm wide beam. The beam is directed by the mirror to propagate orthogonally to the bottom surface of the plate with cell culture under exposure.
Fig. 3
Fig. 3
The number of live cells and cells at early and late stages of apoptosis in the sample in relation of the THz radiation exposure time.
See this image and copyright information in PMC

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