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Randomized Controlled Trial
. 2017 May;77(6):647-653.
doi: 10.1002/pros.23312. Epub 2017 Jan 19.

Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG

Rebecca E Graff  1   2 , Gregory Judson  3 , Thomas U Ahearn  1 , Michelangelo Fiorentino  1   4   5 , Massimo Loda  4   6 , Edward L Giovannucci  1   7   8 , Lorelei A Mucci  1   7 , Andreas Pettersson  1   9
Affiliations
Randomized Controlled Trial

Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG

Rebecca E Graff et al. Prostate. 2017 May.

Abstract

Background: Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer.

Methods: We conducted a nested case-control study, including 370 cases and 2,470 controls, to evaluate associations between pre-diagnostic α- and β-carotene, α- and γ-tocopherol, β-cryptoxanthin, lutein, lycopene, retinol, and selenium with the risk of prostate cancer by ERG protein expression status (a marker of TMPRSS2:ERG). Multivariable unconditional polytomous logistic regression was used to calculate odds ratios and 95% confidence intervals.

Results: We did not find any of the antioxidants to be significantly associated with the risk of prostate cancer according to ERG status.

Conclusions: The results do not support the hypothesis that circulating pre-diagnostic antioxidant levels protect against developing TMPRSS2:ERG positive prostate cancer. Additional studies are needed to explore mechanisms for the development of TMPRSS2:ERG positive disease. Prostate 77: 647-653, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: biomarkers; epidemiology; molecular subtypes.

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