Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May 4;8(3):303-309.
doi: 10.1080/19490976.2017.1279377. Epub 2017 Jan 19.

Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease

Krista M Newman  1 , Kevin M Rank  1 , Byron P Vaughn  1 , Alexander Khoruts  1   2
Affiliations

Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease

Krista M Newman et al. Gut Microbes. .

Abstract

We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss several challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward.

Keywords: Crohn's disease; clostridium difficile; fecal microbiota transplantation; inflammatory bowel disease; ulcerative colitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Clayton EM, Rea MC, Shanahan F, Quigley EM, Kiely B, Hill C, Ross RP. The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission. Am J Gastroenterol 2009; 104:1162-9; PMID: 19319128; http://dx.doi.org/10.1038/ajg.2009.4 - DOI - PubMed
    1. Ben-Horin S, Margalit M, Bossuyt P, Maul J, Shapira Y, Bojic D, Chermesh I, Al-Rifai A, Schoepfer A, Bosani M, et al.. Prevalence and clinical impact of endoscopic pseudomembranes in patients with inflammatory bowel disease and Clostridium difficile infection. J Crohns Colitis 2010; 4:194-8; PMID: 21122505; http://dx.doi.org/10.1016/j.crohns.2009.11.001 - DOI - PubMed
    1. Wadhwa A, Al Nahhas MF, Dierkhising RA, Patel R, Kashyap P, Pardi DS, Khanna S, Grover M. High risk of post-infectious irritable bowel syndrome in patients with Clostridium difficile infection. Aliment Pharmacol Ther 2016; 44:576-82; PMID: 27444134; http://dx.doi.org/10.1111/apt.13737 - DOI - PMC - PubMed
    1. Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R, Mitton S, Orchard T, Rutter M, Younge L, et al.. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011; 60:571-607; PMID: 21464096; http://dx.doi.org/10.1136/gut.2010.224154 - DOI - PubMed
    1. Kelsen JR, Kim J, Latta D, Smathers S, McGowan KL, Zaoutis T, Mamula P, Baldassano RN. Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis 2011; 17:50-5; PMID: 20722068; http://dx.doi.org/10.1002/ibd.21421 - DOI - PubMed

LinkOut - more resources