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Meta-Analysis
. 2017 Feb 10;11(1):016011.
doi: 10.1088/1752-7163/aa5a8a.

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate

Adam M Peel  1 , Christina-Jane Crossman-Barnes, Jonathan Tang, Stephen J Fowler, Gwyneth A Davies, Andrew M Wilson, Yoon K Loke
Affiliations
Free article
Meta-Analysis

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate

Adam M Peel et al. J Breath Res. .
Free article

Abstract

Objectives: We aimed to assess the evidence for the use of 8-isoprostane in exhaled breath condensate (EBC) as a biomarker in adult asthma.

Design: A systematic review and meta-analysis of EBC 8-isoprostane.

Methods: We searched a number of online databases (including PubMed, Embase and Scopus) in January 2016. We included studies of adult non-smokers with EBC collection and asthma diagnosis conducted according to recognised guidelines. We aimed to pool data using random effects meta-analysis and assess heterogeneity using I 2.

Results: We included twenty studies, the findings from which were inconsistent. Seven studies (n = 329) reported 8-isoprostane levels in asthma to be significantly higher than that of control groups, whilst six studies (n = 403) did not. Only four studies were appropriate for inclusion in a random effects meta-analysis of mean difference. This found a statistically significant between-groups difference of 22 pg ml-1. Confidence in the result is limited by the small number of studies and by substantial statistical heterogeneity (I 2 = 94).

Conclusion: The clinical value of EBC 8-isoprostane as a quantitative assessment of oxidative stress in asthma remains unclear due to variability in results and methodological heterogeneity. It is essential to develop a robust and standardised methodology if the use of EBC 8-isoprostane in asthma is to be properly evaluated.

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