Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan 19;17(1):59.
doi: 10.1186/s12906-017-1564-z.

Pharmacological profile of the aerial parts of Rubus ulmifolius Schott

Niaz Ali  1 , Mohammad Shaoib  2 , Syed Wadood Ali Shah  2 , Ismail Shah  2   3 , Muhammad Shuaib  2
Affiliations

Pharmacological profile of the aerial parts of Rubus ulmifolius Schott

Niaz Ali et al. BMC Complement Altern Med. .

Abstract

Background: As aerial parts of Rubus ulmifolius contains phytochemicals like flavonoids and tannins. And whereas flavonoids and tannins have antioxidant and antipyretic activity, hence, current work is carried out to screen crude methanolic extract of aerial parts of Rubus ulmifolius (Ru.Cr) and crude flavonoids rich extract of Rubus ulmifolius (Ru.F) for possible antioxidant and antipyretic activity. Ru.Cr and Ru.F are also tested for brine shrimps lethality bioassay. Ru.F is tested for the first time for possible antioxidant and antipyretic activity.

Methods: Preliminary phytochemical screening of Ru.Cr and Ru.F was performed as it provides rapid finger printing for targeting a pharmacological activity. Acute toxicity and Brine shrimps' cytotoxicity studies of Ru.Cr and Ru.F were performed to determine its safe dose range. Antioxidant and antipyretic studies were also performed as per reported procedures.

Results: Ru.Cr tested positive for presence of tannins, alkaloids, flavonoids and steroids. Ru.Cr is safe up to 6 g/kg following oral doses for acute toxicity study. Ru.Cr is safe up to 75 μg/kg (p.o), LC50 for Ru.Cr and Ru.F are 16.7 ± 1.4 μg/ml 10.6 ± 1.8 μg/ml, respectively (n = 3). Both Ru.Cr and Ru.F demonstrated comparable antioxidant activity using vitamin C as standard (p ≤ 0.05). In test dose of 300 mg of Ru.Cr, rectal temperature was reduced by 74% (p ≤ 0.05) on 4th hour of the administration. More, Ru.F produced 72% reduction in pyrexia (p ≤ 0.05) on 4th hour of administration of paracetamol in Westar rats.

Conclusions: The current work confirms that aerial parts of Rubus ulmifolius contain flavonoids that are safe up to 6 g/kg (p.o). Crude methanolic extract and flavonoids rich fraction of Rubus ulmifolius have significant antioxidant and antipyretic activity. Further work is required to isolate the pharmacologically active substances for relatively safe and effective antipyretics and antioxidants.

Keywords: Antioxidant; Antipyretic; Brewer’s yeast; Flavonoids; Paracetamol; Pyrexia; Rubus ulmifolius.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ballabh B, Chaurasia O, Ahmed Z, Singh SB. Traditional medicinal plants of cold desert Ladakh—used against kidney and urinary disorders. J Ethnopharmacol. 2008;118(2):331–339. doi: 10.1016/j.jep.2008.04.022. - DOI - PubMed
    1. Finn RD, Tate J, Mistry J, Coggill PC, Sammut SJ, Hotz H-R, Ceric G, Forslund K, Eddy SR, Sonnhammer EL. The Pfam protein families database. Nucleic Acids Res. 2008;36(suppl 1):D281–D288. - PMC - PubMed
    1. Hummer G. Molecular binding: Under water’s influence. Nat Chem. 2010;2(11):906–907. doi: 10.1038/nchem.885. - DOI - PMC - PubMed
    1. Patel-Schneider PF, Hayes P, Horrocks I. OWL web ontology language semantics and abstract syntax. W3C Recomm. Available on: http://www.w3.org/TR/2004/REC-owl-semantics-20040210/.
    1. Moyer A, Finney JW, Swearingen CE, Vergun P. Brief interventions for alcohol problems: a meta‐analytic review of controlled investigations in treatment‐seeking and non‐treatment‐seeking populations. Addiction. 2002;97(3):279–292. doi: 10.1046/j.1360-0443.2002.00018.x. - DOI - PubMed

LinkOut - more resources