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Review
. 2017 Jan 20;120(2):267-269.
doi: 10.1161/CIRCRESAHA.116.310115.

Oncometabolic Tracks in the Heart

Heinrich Taegtmeyer  1 , Anja Karlstaedt  2 , Meredith L Rees  2 , Giovanni Davogustto  2
Affiliations
Review

Oncometabolic Tracks in the Heart

Heinrich Taegtmeyer et al. Circ Res. .

Abstract

The term cancer and the heart is readily associated with the cardiotoxicity of antineoplastic agents, such as anthracyclines or receptor tyrosine kinase inhibitors. This Viewpoint offers a different perspective, drawing attention to the consequences of metabolic dysregulation in cancers for energy substrate metabolism and contractile function of the heart and to common cellular strategies present in cancers and in the failing heart.

Keywords: fetal heart; heart; heart failure; isocitrate dehydrogenase; metabolism; neoplasms; pyruvate kinase.

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