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Review
. 2017 Jan 20;120(2):270-273.
doi: 10.1161/CIRCRESAHA.116.310060.

Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field

Joshua D Hutcheson  1 , Mark C Blaser  1 , Elena Aikawa  2
Affiliations
Review

Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field

Joshua D Hutcheson et al. Circ Res. .
No abstract available

Keywords: atherosclerosis; calcification; hyperphosphatemia; inflammation; valve.

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Figures

Figure 1
Figure 1. Mechanisms of Calcification
Various mineralization modes may co-exist within a tissue. Hyperphosphatemia leads to rapid tissue calcification via EV-mediated mineral nucleation and osteochondrogenesis. Inflammation-mediated calcification may be driven by osteochondral differentiation of resident SMCs/VICs, leading to loading of TNAP into EVs, producing free phosphate. Alternatively, inflammation may stimulate osteogenic differentiation or drive cell death. Microcalcifications in the fibrous cap may potentiate rupture, and macrocalcification may stabilize atherosclerotic plaque but are responsible for impairment of valve opening/closure.
See this image and copyright information in PMC

References

    1. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:e38–e360. - PubMed
    1. Otto CM, Burwash IG, Legget ME, Munt BI, Fujioka M, Healy NL, Kraft CD, Miyake-Hull CY, Schwaegler RG. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation. 1997;95:2262–2270. - PubMed
    1. Rapp AH, Hillis LD, Lange RA, Cigarroa JE. Prevalence of coronary artery disease in patients with aortic stenosis with and without angina pectoris. Am J Cardiol. 2001;87:1216–1217. a7. - PubMed
    1. Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA. Osseous and chondromatous metaplasia in calcific aortic valve stenosis. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2016;25:18–24. - PubMed
    1. Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E. Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. J Mol Cell Cardiol. 2016 - PMC - PubMed

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