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Review
. 2016 Dec 23:5:2912.
doi: 10.12688/f1000research.9691.1. eCollection 2016.

Recent advances in understanding neutrophils

Justin F Deniset  1 , Paul Kubes  2
Affiliations
Review

Recent advances in understanding neutrophils

Justin F Deniset et al. F1000Res. .

Abstract

Neutrophils have long been regarded as key effectors of the innate immune response during acute inflammation. Recent evidence has revealed a greater functional diversity for these cells than previously appreciated, expanding roles for neutrophils in adaptive immunity and chronic pathologies. In this review, we summarize some of the evolving paradigms in the neutrophil field and highlight key advances that have contributed to our understanding of neutrophil behavior and function in vivo. We examine the concept of neutrophil subsets and polarization, we discuss novel immunomodulatory roles for neutrophils in shaping the immune response, and, finally, we identify technical advances that will further enhance our ability to track the function and fate of neutrophils.

Keywords: heterogeneity; immunomodulation; neutrophils.

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Conflict of interest statement

The authors declare that they have no competing interests. No competing interests were disclosed. No competing interests were disclosed.

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