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. 2017 Jan 5:3:72.
doi: 10.3389/fmed.2016.00072. eCollection 2016.

Acellular Dermal Matrix (Permacol®) for Heterologous Immediate Breast Reconstruction after Skin-Sparing Mastectomy in Patients with Breast Cancer: A Single-Institution Experience and a Review of the Literature

Laura Knabben  1 , Gowthami Kanagalingam  1 , Sara Imboden  1 , Andreas R Günthert  2
Affiliations

Acellular Dermal Matrix (Permacol®) for Heterologous Immediate Breast Reconstruction after Skin-Sparing Mastectomy in Patients with Breast Cancer: A Single-Institution Experience and a Review of the Literature

Laura Knabben et al. Front Med (Lausanne). .

Abstract

Objective: Skin-sparing mastectomy (SSM) with immediate heterologous reconstruction is a safe oncological option in surgical therapy of early breast cancer. Permacol® is an acellular dermal matrix (ADM) placed between the implant and the skin to improve lower pole projection and implant coverage. The aim of our study was to evaluate the outcome with a focus on patient satisfaction after 6 months and to analyze physical changes of ADM.

Methods: 10 patients who underwent SSM with Permacol® were analyzed retrospectively. All patients were followed using a satisfaction questionnaire and an ultrasound evaluation of the tissue thickness of the pectoralis muscle and the Permacol®.

Results: No intraoperative complications were observed. One patient required removal of the implant for necrosis after 3 months. Half of the patients underwent secondary corrective surgery. A statistically significant thinning of the pectoralis muscle was observed, compared to the thickening of the Permacol®. A majority of the patients were satisfied with the operation, and we found a correlation between lower body mass index and patient satisfaction.

Conclusion: In our small case series Permacol®-assisted immediate reconstruction is shown to be an option for selected cases. Physical changes of Permacol® result in a symmetrical coverage of the implant, which may improve cosmetic outcome.

Keywords: Permacol®; acellular dermal matrices; breast cancer; heterologous immediate breast reconstruction; skin-sparing mastectomy.

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Figures

Figure 1
Figure 1
Intraoperative placement of the implant and Permacol®.
Figure 2
Figure 2
Defined locations of thickness measurements of the Permacol® and pectoral muscle.
Figure 3
Figure 3
Correlation between BMI and patient’s satisfaction.
See this image and copyright information in PMC

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