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Review
. 2017 Apr;50(2):e12329.
doi: 10.1111/cpr.12329. Epub 2017 Jan 19.

NEAT1: A novel cancer-related long non-coding RNA

Xin Yu  1 , Zheng Li  2 , Heyi Zheng  1 , Matthew T V Chan  3 , William Ka Kei Wu  3   4
Affiliations
Review

NEAT1: A novel cancer-related long non-coding RNA

Xin Yu et al. Cell Prolif. 2017 Apr.

Abstract

Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1. Further investigations are warranted to elucidate the upstream and downstream mechanisms of NEAT1 overexpression.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Genomic structure of NEAT1‐1 and NEAT1‐2. A screenshot was captured from UCSC genome browser
Figure 2
Figure 2
Proposed oncogenic action of NEAT1 in solid tumours. NEAT1 acts as a competing endogenous lncRNA to sponge tumour‐suppressive microRNAs to mediate its pro‐tumourigenic action
See this image and copyright information in PMC

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